For classes, teachers, classrooms and subjects you can define so called "Time-off". It defines when lessons can be (green), and when they cannot be (red). You can also define so called "question marked positions", where lessons can be, but you wish to avoid having lessons there:
You can click on an individual cell to change its status, or you can click on a column or a row header to change whole day status. So if your teacher cannot come on Friday, simply click on the Friday's row header and the whole Friday will be blocked.
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